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2005 MCS Divisional Seminars & Colloquia |
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Genomic networks: From development to diseaseKevin P. White Yale University
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| Abstract | Genome science affords new opportunities to study complex biological processes and applications. By studying individual biomolecules in the context of their pathway and network topologies, genome scientists are beginning to understand the inherent rules and emergent properties of genomic networks - and their relation to biological complexity - in ways that will have wide ranging ramifications throughout science and industry. In my laboratory we take advantage of the powerful genetic and genomic tools and well-studied developmental pathways of the common fruit fly (Drosophila) to create accurate models of complex biological networks such as those involved in steroid signaling and in early embryonic patterning. In collaboration with computational scientists we are working to integrate diverse genomic and computational data to predict topological relationships critical to understanding complex biological processes including cancer and genetic disorders in humans. |
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